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lipid-coated nanoparticle

PEGylated liposome (STEALTH® liposomes) is the second generation liposome system. It offers significant advantages over conventional liposomes. It has prolonged blood circulation time and hence enhanced drug accumulation at the disease site. Other potential benefits include reduced toxicity, reduced dosing frequency etc.

Targeted Liposome

This is the most advanced liposome system. PEGylated liposomes with targeting ligands (antibodies, antibody fragments, peptides and small molecules) have the potential of specific targeted delivery to the disease site through ligand-receptor binding

 
Text Box: Technology We specialize in a range of formulation and drug delivery technologies from solubility enhancement using liposomes, lipospheres and micellar systems to more sophisticated nano-enabled systems like PEGylated liposomes, PEGylated lipospheres and polymer-based nanoparticles for controlled/sustained delivery of various type of compounds. We have strong expertise and many years of experience in designing and developing parenteral delivery systems with respect to both the drug carrier systems and the drug loading methods for challenging compounds. Our goal is to come up with formulation solutions that are tailored and optimized to fit the compound and the specific need of our partners/customers. Our Expertise Development of new carriers and drug loading technologies Conventional liposomes Long-circulating PEGylated liposomes Lipid-based nanoparticles or lipid-particles Other types of nano-enabled systems Optimization of formulation parameters using DOE (Design of Experiments) Potential Benefits with Our Technology Accumulation enhancement at the disease site through prolonged circulation Improve PK/PD relationship Increase in therapeutic efficacy Reduction in dosing frequency Solubilization of water-insoluble compounds Reduction in toxicity Stability enhancement

Conventional liposomes This is the first generation liposome system. Various types of drugs can be loaded into the interior, in the bilayer or at the interface depending on the nature of the compounds.

 

STEALTH(r) liposomeTargeted LiposomeConventional Liposome

PEG-lipid  monolayer coated drug nanoparticles to provide high drug payload and prolonged circulation
lipid-coated nanoparticlelipid-coated nanoparticlelipid-coated nanoparticle

PEGylation

Monolayer lipid-coating

Drug-nanoparticle